Infrastructure

Our Infrastructure

The state-of-the-art ‘Laboratory Animal Breeding and Research Facility’ spreads over more than 10,000 Sq.ft designed and built in compliance with CPCSEA guidelines with international standards set for the quality breeding and experimental research. The facility is registered with CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals) approval vide No. 1899/PO/Bt/S/16/CPCSEA

The facility is designed and built to accommodate different strains  and their matrices (Plasma, Serum, whole Blood, Organs) of laboratory animal species, which include – Rats, Mice, Rabbits, Guinea pig.

Salient Features

State-of-the-art more than 10,000 Sq.Ft conventional housing quality breeding and services facility
Class 100,000 facility with efficient HVAC systems covered animals breeding and stock with 100% pass through air circulation
3 level pressure gradient system appropriate with supply and return corridors
Provision of distinctly separated and wide Clean and Service Corridors connected all areas for the quality operations
Dedicated areas with separate entry and exit for Rodent and non-rodent breeding, housing, experimentation & other services
Provision of different AHU for each operational areas like Breeding and stock rooms
Strong back up for the critical systems to maintain quality system and colony.
Authorized and Biometric Access Control with restricted entry to the breeding areas
Equipments

Quality instruments and equipments to maintain standard system to generate high quality  in the husbandry care or research activities. Few of which include Refrigerated Centrifuge, Heavy Duty Autoclaves (2), Refrigerators, Freezer, Reverse Osmosis Water Systems, etc.

Drinking Water

Potable, Reverse Osmosis with UV treated water Ad libitum to all the animals. Rigorous system to check routine water system quality include chemical and microbial count evaluation in contaminant analysis  annually once.

Feed
Feed is provided Ad libitum, unless the study protocol specifications or restrictions. Samples are sent routinely for proximate/nutritional and contamination analysis.
Feed Storage

Rodent diets are stored in dedicated rooms in the facility with vermin proof and temperature controlled environment. Feed bags are stored off the floor, stacked away from walls to allow for air circulation as well as pest control. The contamination analysis including chemical, pesticides and microbial monitoring outsourced to asses once in year.

Bedding

Corncob is the bedding material used for Rodents and Rabbits or G.Pig are maintained with the solid bottom cages. The sterilized bedding material is used after appropriate autoclaving process.

Bedding Storage

Dedicated bedding material storage room provided in the facility. Bedding material/corn cob is stored off the floor, on the pallets and stacked away from walls to allow air circulation. Monitors samples for the contaminant analysis including pesticides, bacterial contaminations and microbial once in a year. 

Light, Photoperiod and Air Changes

Species Light Intensity (LUX) Photoperiod In Hours (L:D) Air Changes Per Hour
Rat And Mouse 325-400 12:12 15-20
Rabbit and Guinea Pig 325-400 12:12 15-20

Temperature and Humidity

The temperature of all animal rooms are controlled with an ambient temperature with 22 + 3 °C. Humidity of all animal rooms is controlled at 30-70% and monitored continuously. 

Washing & Utility

All cages, cage tops, water bottles, etc. are autoclaved before entering into the clean area. The dedicated and spacious washing area connected all the facility through service corridor to carry washable material. The washing process consists of three standard stages:

  1. De-husking:  Bedding disposal area is dedicated and used to de-husk the used cages.
  2. First wash: The de-husked cages are flushed with water forcefully to remove all solid waste attached to gets cleaned.
  3. Soaking:  A tank containing detergent solution used to dip the cages to  soak for 15 to 20 minutes. 
  4. Final wash: After soaking in the detergent, the final wash of cages are done with forced water flow.
  5. Drying:  After final wah, the cages are finally placed for the drying to proceed to autoclave before use.

Man and Material Movements

The material entry, man entry and operational areas are isolated and restricted to facilitate standard material and man movements. The internal operations are followed through dedicated clean or service corridors and flow channels.